Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study)
| Autor: | Catherine Laska, Katherine Scolari Childress, Jeffrey A. Gavard, Sara Lebovitz, Christina Dothager, Dorothea Mostello |
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| Rok vydání: | 2018 |
| Předmět: |
Pregnancy
Metoclopramide business.industry Diphenhydramine Codeine Obstetrics and Gynecology medicine.disease Acetaminophen law.invention 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Randomized controlled trial law Anesthesia Pediatrics Perinatology and Child Health Medicine 030212 general & internal medicine Headaches medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | American Journal of Perinatology. 35:1281-1286 |
| ISSN: | 1098-8785 0735-1631 |
| Popis: | Objective We investigated whether metoclopramide administered with diphenhydramine (MAD) relieves headache in pregnant women when acetaminophen alone is ineffective, using codeine for comparison. Study Design Normotensive pregnant women in the second or third trimester were randomized to MAD intravenously (10 mg and 25 mg, respectively) or codeine orally (30 mg) for headache after 650 to 1,000 mg of acetaminophen failed to relieve their headaches. Headache severity (pain score 0–10) was noted at intervals over 24 hours. The primary outcome was reduction in pain score 6 hours after medication administration. A sample size calculation of 35 patients per group was based on estimated reduction in headache pain score by at least two points, with an α of 0.05 and a power of 80%. Results No difference was seen in the primary outcome. MAD pain scores were lower at 30 minutes (3 ± 2.8 versus 5.8 ± 2.3, p Conclusion MAD effectively relieves headaches in pregnant women when acetaminophen fails. |
| Databáze: | OpenAIRE |
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