Parenteral administration of trypsin triggers lung emphysema
| Autor: | E Reichart, P Boerkmann, F Plenat |
|---|---|
| Rok vydání: | 1992 |
| Předmět: | |
| Zdroj: | European Respiratory Journal. 5:810-814 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.93.05070810 |
| Popis: | Eight weeks after a single intravenous injection of trypsin, more than half of 26 treated rats showed pulmonary emphysema, as demonstrated by a significant increase of the mean linear intercept (MLI = 107 microns) in comparison with 11 controls (69 +/- 15 microns) (mean +/- SD). As observed 56 days after the injection, the intraperitoneal administration of trypsin (24 rats) also leads to lung emphysema (MLI = 101-106 microns), as does endotracheal instillation of elastase (13 rats), (MLI = 108 microns). The intraperitoneal administration of trypsin in animals constitutes a model close to human pathology with which lung alterations in acute pancreatitis may be studied. Having no elastolytic properties, trypsin cannot directly induce emphysema. The observation of a pulmonary leucostasis in eight rats sacrificed early after the trypsin injection suggested that leucocyte trapping and activation are important for the genesis of this trypsin-triggered emphysema. |
| Databáze: | OpenAIRE |
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