Hydrothermal fabrication of mesoporous carbonated hydroxyapatite microspheres for a drug delivery system
| Autor: | Ya-Jun Guo, Ya-Ping Guo, Yong-bo Yao, Congqin Ning |
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| Rok vydání: | 2012 |
| Předmět: |
Simulated body fluid
Nanoparticle Mineralogy General Chemistry Condensed Matter Physics Phosphate Apatite chemistry.chemical_compound Calcium carbonate chemistry Chemical engineering Mechanics of Materials visual_art Drug delivery visual_art.visual_art_medium General Materials Science Particle size Mesoporous material |
| Zdroj: | Microporous and Mesoporous Materials. 155:245-251 |
| ISSN: | 1387-1811 |
| Popis: | Mesoporous carbonated hydroxyapatite microspheres (MCHMs) with a particle size of ∼5 μm have been fabricated hydrothermally by soaking calcium carbonate microspheres (CCMs) in a disodium hydrogen phosphate solution at 140 °C. The transformation mechanism is a dissolution–precipitation reaction. After soaking in the disodium hydrogen phosphate solution, the calcium ions released from the CCMs react with phosphate ions in the solution to form carbonated hydroxyapatite nanoparticles. These nanoparticles aggregate to form mesopores with the pore size of 4.0–14.0 nm. The MCHMs have been tested as vancomycin delivery systems due to the presence of the OH units in the carbonated hydroxyapatite structure, which provide these carriers of great affinity towards host drug molecules. In addition, in vitro tests into a simulated body fluid (SBF) demonstrate that the MCHMs are bioactive, since an apatite layer deposits on their surfaces after 3 days of assay. Such MCHMs could be useful in developing new biomaterials and have potential use in implanting and drug delivery for tissue regeneration. |
| Databáze: | OpenAIRE |
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