| Autor: | Bruce B. Jarvis, Kati Huttunen, Maija-Riitta Hirvonen, Anne Hyvärinen, Birgitte Andersen, Kristian Fog Nielsen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Veterinary (miscellaneous)
Metabolite Stachybotrys Inflammation Biology biology.organism_classification Applied Microbiology and Biotechnology Microbiology chemistry.chemical_compound chemistry medicine Macrophage Bioassay Cytotoxic T cell Tumor necrosis factor alpha medicine.symptom Cytotoxicity Agronomy and Crop Science |
| Zdroj: | Mycopathologia. 154:201-206 |
| ISSN: | 0301-486X |
| DOI: | 10.1023/a:1016383402963 |
| Popis: | The metabolite profiles of 20 Stachybotrys spp.isolates from Finnish water-damaged buildings were compared with their biological activities. Effects of purified compounds on cytotoxicity and production of inflammatory mediators such as nitric oxide, IL-6 and TNFα in murine RAW264.7 macrophage cells were studied. The 11isolates belonging to the satratoxin-producing chemotype were highly cytotoxic to the macrophages. The isolates inducing inflammatory mediators all belonged to the atranone-producing chemotype, but pure atranones B, and D did not elicit a response in the bioassay. Altogether, cytotoxicity ofStachybotrys sp. isolates appear to be related to satratoxin production whereas the specific component inducing inflammatory responses in atranone-producing isolates remains obscure. |
| Databáze: | OpenAIRE |
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