Effet De LaS-Adénosyl-L-Méthionine Sur Le Métabolisme Cérébral Et Périphérique De La L-Dopa(1)

Autor:	P. Fonlupt, J.-N. Bidard, Henri Pacheco, L. Cronenberger
Rok vydání:	1978
Předmět:	Kidney medicine.medical_specialty Physiology Central nervous system Normetanephrine Biochemistry Midbrain chemistry.chemical_compound Norepinephrine medicine.anatomical_structure Endocrinology Biosynthesis chemistry Dopamine Internal medicine medicine Brainstem medicine.drug
Zdroj:	Archives Internationales de Physiologie et de Biochimie. 86:715-724
ISSN:	0003-9799
DOI:	10.3109/13813457809069524
Popis:	The repartition of [3H]L-dopa administred i.p. does not change in rats treated with 5-adenosyl-L-methionine (SAM). The effect was studied on the central nervous system and at the periphery. The biosynthesis of metabolites [3H]dopamine and [3H]3-O-methyldopamine are also unchanged.On the other hand, in the kidney an accumulation of [3H]norepinephrine +[3H]normetanephrine was observed, while in the brainstem + midbrain the synthesis of these metabolites was decreased after SAM injection.The relations between these biochemical results and the pharmacological antiparkinsonian effects are discussed.
Databáze:	OpenAIRE
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