Management of new onset diabetes after transplantation (NODAT) with use of novel algorithm

Autor:	Om J. Lakhani
Rok vydání:	2019
Předmět:	Graft failure business.industry Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism medicine.disease Transplantation Calcineurin 03 medical and health sciences 0302 clinical medicine New onset diabetes Diabetes mellitus Internal Medicine medicine Outpatient clinic In patient 030212 general & internal medicine business Algorithm Glycemic
Zdroj:	International Journal of Diabetes in Developing Countries. 39:768-773
ISSN:	1998-3832 0973-3930
DOI:	10.1007/s13410-019-00741-2
Popis:	Corticosteroids, calcineurin inhibitors, and mTOR inhibitors are often used as an immunosuppressant in patients after solid-organ transplant. These agents can lead to significant hyperglycemia which is called “New onset of diabetes after transplantation (NODAT)”. Tight-glycemic control in patients with NODAT not only reduces the risk of post-transplant infection and graft failure but also reduces the long-term morbidity and mortality. Management of patients with NODAT is complicated because changes in doses of immunosuppressant can lead to change in glycemic status. Here, we present a series of cases involving successful management of hyperglycemia among outpatient department (OPD) patients with NODAT using a novel algorithm which negates the glycemic effects of corticosteroids and calcineurin inhibitors. We have also described the basic components of the algorithm which can be useful for physicians who deal with NODAT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f35368fd80a250b450c333c0da30d9b1 https://doi.org/10.1007/s13410-019-00741-2 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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