Effect of a Heat-Stable Toxin of Yersinia pseudotuberculosis on the Functional and Phenotypic Traits of Two Types of Phagocytes in the Holothurian Eupentacta fraudatrix

Autor:	L. S. Dolmatova, O. A. Ulanova, N. F. Timchenko
Rok vydání:	2021
Předmět:	Toxin Virulence Phenotypic trait Glutathione Biology biology.organism_classification medicine.disease_cause Phenotype General Biochemistry Genetics and Molecular Biology Microbiology Eupentacta fraudatrix chemistry.chemical_compound chemistry Apoptosis medicine Yersinia pseudotuberculosis General Agricultural and Biological Sciences
Zdroj:	Biology Bulletin. 48:395-406
ISSN:	1608-3059 1062-3590
DOI:	10.1134/s1062359021040051
Popis:	The impact of a heat-stable toxin of Yersinia pseudotuberculosis (HSTYp) on the markers of functional activity and phenotypes of P1- and P2-type phagocytes was studied in the holothurian Eupentacta fraudatrix. In the control, P1 and P2 phagocytes differed in the levels of apoptosis and reduced glutathione, as well as in the surface receptor binding to some plant lectins. HSTYp (0.2–2 μg/mL) caused a shift in the functional activity and phenotype of P1 phagocytes toward the prevalence of those characteristic of the P2 type, which has a lower bactericidal activity. It is supposed that HSTYp is an important factor in the reprogramming of holothurian phagocytes toward the predominance of the anti-inflammatory type, which may increase the virulence of Y. pseudotuberculosis for holothurians.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f34b31cd69183108799bd160c3dfc257 https://doi.org/10.1134/s1062359021040051 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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