| Autor: |
Daniela Denis Di Martino, Elisa Sabattini, Valentina Giardini, Gabriele Tinè, Vittoria Sterpi, Mariachiara Lonardoni, Eleonora Acampora, Marco Parasiliti, Ilaria Ramezzana, Tatjana Radaelli, Manuela Wally Ossola, Tamara Stampalija, Patrizia Vergani, Enrico Ferrazzi |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-1244058/v1 |
| Popis: |
Objectives Hypertensive disorders of pregnancy (HDP) and fetal growth restriction (FGR) of vascular placental origin are two main pregnancy complications associated with an increased incidence of poor outcomes. These conditions are both characterized by vascular dysfunction and syncytiotrophoblast oxidative stress. sFlt-1/PlGF ratio as an index of oxidative stress could be a valid diagnostic tool for predicting adverse perinatal outcomes in high risk population. Methods We recruited women affected by HDP, classified according to fetal growth or with isolated FGR. Women with an uneventful pregnancy were recruited as control group. Ultrasound data and sera sample were collected at recruitment. Perinatal complications were the main outcome of this diagnostic study. A survival analysis, a logistic regression model with all covariates and a predictive model based on a Random Forest and a Mean Decrease Gini index were performed. Results We recruited 350 consecutive singleton pregnancies. The 90 patients who suffered of perinatal complications had a significantly higher sFlt-1/PlGF ratio (267.2±271.2) at recruitment than those who did not (57±93.5), (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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