Seasonal Variation of the Water Quality of the Senegal River (Mauritania)
| Autor: | Abdoulaye Demba N'diaye, Mohamed Ould Sid’Ahmed Ould Kankou |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | International Journal of Chemical and Process Engineering Research. 1:1-9 |
| ISSN: | 2313-0776 2313-2558 |
| DOI: | 10.18488/journal.65/2014.1.1/65.1.1.9 |
| Popis: | The 2-{[5-(2-Amino-4-oxoquinazolin-3(4 H )-yl)-1,3,4-thiadiazol-2-yl]methyl}-1 H -isoindole-1,3(2 H )-dione 1 was synthesized and allowed to react with each of p -methoxybenzaldehyde, Â p -methoxyacetophenone and chloroacetyl chloride to produce the Schiff bases 2 and 3 and 2-chloro- N -(3-{5-[(1,3-dioxo-1,3-dihydro-2 H -isoindol-2-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-oxo-3,4-dihydroquinazolin-2-yl)acetamide 6 , respectively. The products 2 and 3 were reacted with phenyl isothiocyanate to afford 4 and 5 . Derivative 6 was reacted with various nucleophiles, namely: thioglycolic acid, ethyl glycinate and 2-aminoethanol giving 7-9 respectively. In turn, the derivative 8 was reacted with I±-bromoglucose tetraacetate affording product 8a whereas 9 was reacted with p -acetylaminobenzenesulfonyl chloride affording derivative 9a . Moreover, the reactions of the derivative 6 with potassium thiocyanate, potassium cyanate, malonitrile, ethyl cyanoacetate and ammonium acetate gave derivatives 10-15 , respectively. All the synthesized derivatives were confirmed by the IR, mass, 1 H-NMR and elemental analysis. Key words: Quinazolinyl thiazolidine, thioxodiazetidinyl quinazoline, piperazinyl quinazolinone, thiomorpholine and triazinoquinazoline. |
| Databáze: | OpenAIRE |
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