Analysis of different factors affecting a liquid chromatographic chiral separation of some imino-hesperetin compounds
| Autor: | Hassan Y. Aboul-Enein, Khaled Sekkoum, Jose Carlos Menendez Ramos, Nasser Belboukhari, Mohammed El Amin Zaid |
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| Rok vydání: | 2019 |
| Předmět: |
Carbon chain
Chromatography Resolution (mass spectrometry) Chemistry General Chemical Engineering General Engineering Hesperetin General Physics and Astronomy High-performance liquid chromatography Chiral resolution Chromatographic separation chemistry.chemical_compound General Earth and Planetary Sciences General Materials Science General Environmental Science |
| Zdroj: | SN Applied Sciences. 1 |
| ISSN: | 2523-3971 2523-3963 |
| DOI: | 10.1007/s42452-019-1187-8 |
| Popis: | An investigation was reported concerning the chiral analysis of some Imino-4-Hesperetin and the impact of different factors on their chiral high-performance liquid chromatographic separation. Using Schiff bases reactions, new Imino-4-Hesperetin derivatives had been elaborated by the reaction of Hesperetin with various diamines differ only in their carbon chain length which ranged between 4, 8 and 10 carbons; Yields were very acceptable and ranged between 77 and 89%. A chiral separation was then employed by a conventional HPLC with six different polysaccharide-based chiral stationary phases. The resolution, capacity and separation factors obtained were good (2.11 ≤ Rs ≤ 4.5); (1.25 ≤ k′ ≤ 8.71) and (1.16 ≤ α ≤2.57). Flow rate was about 0.3–0.5 mL/min. The factors affected the chiral resolution including the role of the carbon chain length which did have an impact on the resolution of these derivatives were discussed. |
| Databáze: | OpenAIRE |
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