BACKGROUND: Value of plasma C-reactive protein and lactate dehydrogenase levels in the diagnosis of intestinal obstruction in an emergency department
| Autor: | Francisco Javier Montero-Pérez, Baena-Delgado E, A García-Olid, L M Jiménez-Murillo, J M Calderón de la Barca-Gázquez, J M Gallardo-Valverde, Rafael Calvo-Rodríguez |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
biology Colorectal cancer business.industry C-reactive protein Acute-phase protein Cancer General Medicine Plasma levels medicine.disease Gastroenterology Surgery chemistry.chemical_compound chemistry Clinical history Internal medicine Lactate dehydrogenase medicine biology.protein In patient business |
| Zdroj: | Anales del Sistema Sanitario de Navarra. 39 |
| ISSN: | 1137-6627 |
| DOI: | 10.23938/s1137-6627/2016000100013 |
| Popis: | Background. Intestinal obstruction is one of the most frequent surgical emergencies. Its diagnosis is essentially based on clinical history, physical exploration and image tests. The aim of this study was to analyze the diagnostic value of acute phase reactants in patients with benign versus malign intestinal obstruction. Method. Historical cohort study of 53 patients who underwent surgery because of intestinal obstruction and/or non-obstructive colorectal cancer. The patients were placed in three groups: group 1 (colorectal cancer with intestinal obstruction) (n=23), group 2 (benign intestinal obstruction) (n=10) and group 3 (non-obstructive cancer of the colon) (n=20). We determined the initial plasma values of the C-reactive protein (CRP) and the lactate dehydrogenase (LDH) enzyme. Results. CRP was quantitatively higher in patients with benign intestinal obstruction (group 2) (p=0.001), while LDH was quantitatively higher in group 1 (patients with obstructive cancer). The plasma levels of LDH were significantly greater in the groups with intestinal obstruction (groups 1 and 2) than in patients without obstruction (p 24 ng/l (CI 95 % = 30-82%) and 52% (CI 95% = 29-74%) for levels of LDH > 359 U/L. Conclusion. Determination of plasma concentrations of CRP can help in the diagnosis of intestinal obstruction and indicate its benign or malign origin in emergency services. Key words. Intestinal obstruction. C reactive protein (CRP). Lactate dehydrogenase (LDH). Colorectal cancer. Emergency. |
| Databáze: | OpenAIRE |
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