‘On-solvent’ new domino reaction of salicylaldehyde, malononitrile and 4-hydroxy-6-methylpyridin-2(1 H )-one: fast and efficient approach to medicinally relevant 4-pyridinyl-2-amino-4 H -chromene scaffold

Autor:	Anatoly N. Vereshchagin, Alexander D. Korshunov, Roman A. Novikov, Fedor V. Ryzhkov, Mikhail P. Egorov, Michail N. Elinson
Rok vydání:	2017
Předmět:	Ethanol 010405 organic chemistry General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Solvent chemistry.chemical_compound chemistry Salicylaldehyde Cascade reaction Moiety Organic chemistry Sodium acetate Malononitrile
Zdroj:	Mendeleev Communications. 27:559-561
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2017.11.006
Popis:	Sodium acetate catalyzed assembling of salicylaldehydes, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-one in small amount of ethanol gives rapidly (5 min) substituted 4-pyridinyl-2-amino-4H-chromenes in 82–99% yields. This novel domino reaction opens the fast, facile, and flexible way to the new type of functionalized 2-amino-4H-chromene scaffold containing uracil-like moiety, which are relevant compounds for diverse biomedical applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f33e59c775cce93af176a1cbb0e8b39d https://doi.org/10.1016/j.mencom.2017.11.006 Zobrazit plný text záznamu Full Text from ScienceDirect