Asymmetric aldol reactions catalyzed by the promiscuous aldo–ketoreductase enzyme

Autor:	Normi Mohd Yahaya, Bimo Ario Tejo, Abu Bakar Salleh, Saadi Bayat, Mohd Basyaruddin Abdul Rahman, Emilia Abd Malek
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Mole ratio Enzyme Aldol reaction chemistry Aqueous medium Biocatalysis Organic Chemistry Drug Discovery Organic chemistry Biochemistry Catalysis
Zdroj:	Tetrahedron Letters. 55:6303-6306
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.09.012
Popis:	The promiscuous aldo–ketoreductase (AKR) enzyme is used as a sustainable biocatalyst for the first time to catalyze asymmetric aldol reactions in aqueous medium. The reactions between aromatic aldehydes and cyclic/acyclic ketones give the corresponding products in moderate yields and enantioselectivities in the presence of water. The influence of solvents, the mole ratio of substrates, and enzyme concentration are investigated. The mechanism of the AKR1A1-catalyzed aldol reaction is also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f328dbfeb0abf669be511de5018f537d https://doi.org/10.1016/j.tetlet.2014.09.012 Zobrazit plný text záznamu Full Text from ScienceDirect