18F-fluorination by crown ether-metal fluoride: II. Non-carrier-added labeling method

Autor:	Yosihiko Kasida, Thoshiaki Irie, Tadashi Nozaki, Kiyoshi Fukushi, Tatuo Ido
Rok vydání:	1984
Předmět:	chemistry.chemical_classification Radiation Aqueous solution Inorganic chemistry Evaporation Modified method Ether Metal chemistry.chemical_compound Nuclear Energy and Engineering chemistry visual_art visual_art.visual_art_medium Anhydrous Radiology Nuclear Medicine and imaging Fluoride Crown ether
Zdroj:	The International Journal of Applied Radiation and Isotopes. 35:517-520
ISSN:	0020-708X
DOI:	10.1016/0020-708x(84)90173-x
Popis:	For non-carrier-added 18F-labeling of organic compounds, details were studied concerning the previously developed KF-crown ether method. In the modified method, a minute amount of KOH instead of carrier KF is added for the preparation of the anhydrous 18F from aqueous carrier-free 18F. The following factors were examined in order to determine optimum conditions for the preparation of the anhydrous non-carrier-added 18F and the labeling synthesis with it: effects of the vessel on the evaporation of the 18F-KOH solution and the amount of added KOH for the conversion of aqueous 18F to anhydrous 18F, the solubilized activity of the 18F obtained by the evaporation in organic solutions containing 18-Crown-6 and the labeling reaction, as exemplified by the synthesis of 21-fluoroprogesterone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f324dd8f2dc5b57217c63d8d4d924012 https://doi.org/10.1016/0020-708x(84)90173-x Zobrazit plný text záznamu