Fixed-Charge Generation Derivatization for the Analysis of Carbonyl Compounds by Electrospray Ionization Mass Spectrometry

Autor:	Larisa N. Kulikova, S. V. Goryainov, V. V. Ilyushenkova, Roman S. Borisov, D. I. Zhilyaev
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Chemistry Electrospray ionization 010401 analytical chemistry Selected reaction monitoring Inorganic chemistry 010402 general chemistry Mass spectrometry 01 natural sciences Dissociation (chemistry) 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Fragmentation (mass spectrometry) Mass spectrum Derivatization Alkyl
Zdroj:	Journal of Analytical Chemistry. 75:1665-1670
ISSN:	1608-3199 1061-9348
Popis:	The fixed-charge generation derivatization approach based on a reaction with ω-N,N-dimethylaminoalkylamines followed by quaternization with alkyl halides was applied to the analysis of aliphatic aldehydes and ketones, as well as ketosteroids by electrospray ionization (ESI) mass spectrometry. Both stages of reaction proceed quantitatively, and the registered ESI mass spectra of the products contain abundant peaks of the corresponding ammonium cations. In most cases, the dissociation of the last named compounds under collision activation results only in the loss of the terminal trialkylamino group as a neutral species. Such predictable fragmentation can be used for developing of highly sensitive methods of analysis based on selected reaction monitoring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3219b26a456da196e7edf18fbb5c3bc https://doi.org/10.1134/s1061934820130055 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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