Effect of prenatal application of delta-sleep-inducing peptide and prenatal emotional stress on brain monoamine oxidase and on the behavior of adult male progeny of DD mice

Autor: N. N. Voitenko
Rok vydání: 2008
Předmět:
Zdroj: Neurochemical Journal. 2:197-201
ISSN: 1819-7132
1819-7124
DOI: 10.1134/s1819712408030100
Popis: Prenatal administration of delta-sleep-inducing peptide (DSIP) at a high dose (120 μg per 100 g of body weight) and low dose (12 μg per 100 g of body weight) and prenatal emotional stress resulted in aggressive behavior of two-month-old male progeny of DD mice in the resident-intruder test. However, no increase in the aggressiveness of male progeny of the highly aggressive C57BL mice, which we studied previously, was observed. These data suggest that the prenatal effect of DSIP on the behavior of DD and C57BL mice depended on the individual genotype. The aggressiveness of two-month-old male progeny of the DD mice that were subjected to prenatal treatment with DSIP was accompanied by enhanced activity of monoamine oxidase A (MAO A) in the cerebral hemispheres. These results suggest that DSIP should be considered as a regulatory peptide that controls the expression of the MAO A gene, and that MAO A was probably involved in the development of aggressiveness of the male progeny of the DD mice after the prenatal administration of DSIP. Prenatal emotional stress had no significant influence on the activity of MAO A in the brain of two-month-old male progeny of DD mice. Development of the aggressiveness of two-month-old male progeny of DD mice which were produced by stressed mothers was possibly not associated with fluctuations in the activity of MAO A in the brain.
Databáze: OpenAIRE
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