Efficacy of naftopidil for nocturia in male patients with lower urinary tract symptoms: Comparison of morning and evening dosing
| Autor: | Tomoaki Tanaka, Shinji Yamamoto, Katsuyuki Kuratsukuri, Takahisa Adachi, Rikio Yoshimura, Takahiro Nakamura, Satoshi Tamada, Tetsuo Yamaguchi, Tetsuji Ohmachi, Tatsuya Nakatani |
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| Rok vydání: | 2014 |
| Předmět: |
Gynecology
medicine.medical_specialty Evening Naftopidil business.industry Urology urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Lower urinary tract symptoms Internal medicine medicine Nocturia International Prostate Symptom Score Dosing medicine.symptom business Adverse effect medicine.drug Morning |
| Zdroj: | International Journal of Urology. 22:317-321 |
| ISSN: | 0919-8172 |
| DOI: | 10.1111/iju.12669 |
| Popis: | Objectives To examine the difference in improvement of lower urinary tract symptoms between morning and evening dosing of α1-blocker naftopidil. Methods A total of 177 male patients with nocturia were included in the present study and randomized to morning or evening dosing of naftopidil. The International Prostate Symptom Score, quality of life index and nocturia quality of life index were compared between the two study groups at 12 weeks. Results A total of 143 patients (morning group: n = 70, evening group: n = 73) were analyzed as a result of the dropout of 34 patients because of failure to give consent, adverse events and failure to attend. Nocturia, quality of life index and nocturia quality of life index at 12 weeks were significantly better in the evening group compared with the morning group. In a multivariate model, both the dosing time of naftopidil and the initial nocturia quality of life index were significantly associated with change in nocturia quality of life index. Conclusions Evening dosing of naftopidil seems to be more effective in treating nocturia in male patients with lower urinary tract symptoms. |
| Databáze: | OpenAIRE |
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