Primary Extranodal NK/T-Cell Lymphoma Presenting as Neurolymphomatosis Involving Multiple Cranial Nerves: A Case Report

Autor:	Anne S Renteria, Amir Steinberg, Bruce Petersen, Sharmila Ghosh, Jacques Azzi, Amy M Chan, Kambiz Nael
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Leukemic Infiltration Nerve root medicine.diagnostic_test business.industry Cranial nerves Cauda equina Hematology General Medicine medicine.disease Lymphoma medicine.anatomical_structure Biopsy medicine Etiology T-cell lymphoma business
Zdroj:	Acta Haematologica. 145:97-105
ISSN:	1421-9662 0001-5792
Popis:	Neurolymphomatosis (NL) is a rare condition caused by the lymphomatous or leukemic infiltration of nerves and manifests as neuropathy. Most often, NL is associated with B-lineage non-Hodgkin lymphoma (NHL) and only infrequently occurs in conjunction with T- or NK-lineage NHL. Extranodal NK/T-cell lymphoma (ENKTL)-associated NL is exceedingly unusual, with only 9 cases described in the English language literature, in addition to our case. Diagnosis of NL is challenging, as the entity can mimic neuropathies of more common etiologies, and an adequate biopsy may be difficult to obtain. Timely diagnosis demands a high index of suspicion, especially for patients without a history of hematologic malignancy. We expand upon a unique case of NL exclusively involving cranial nerves and cauda equina nerve roots, as the initial manifestation of ENKTL, and contextualize our findings within the framework of previously reported NK/T-lineage NL cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f31ecb4f2ebf3ce4037d50ca64a3cd14 https://doi.org/10.1159/000518797 Zobrazit plný text záznamu