A Novel Method for the Introduction of Fluorine into the Purine 2-Position: Synthesis of 2-Fluoroadenosine and a Formal Synthesis of the Antileukemic Drug Fludarabine

Autor:	Lise-Lotte Gundersen, Morten Brændvang
Rok vydání:	2006
Předmět:	Drug Purine Chemistry Stereochemistry medicine.drug_class media_common.quotation_subject Organic Chemistry Antimycobacterial Adenosine Catalysis Fludarabine chemistry.chemical_compound Nitration medicine Purine metabolism media_common Fludarabine Phosphate medicine.drug
Zdroj:	Synthesis. 2006:2993-2995
ISSN:	1437-210X 0039-7881
Popis:	A novel method for the introduction of fluorine in the purine 2-position is described and employed in the synthesis of a potential antimycobacterial compound. Also 2-fluoroadenosine has been synthesized for the first time from adenosine with perbenzoylated 2-nitroadenosine as a key intermediate. Mild reaction conditions are employed and few synthetic steps are required. The novel synthesis of fluoroadenosine can be regarded as a formal synthesis of the antileukemic drug fludarabine phosphate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f31bc767a5c65d6c15cdf6e0c1929e99 https://doi.org/10.1055/s-2006-942544 Zobrazit plný text záznamu