Enduracidin, a New Antibiotic. VII. Primary Structure of the Peptide Moiety

Autor:	Toshio Hongo, Isamu Yoshida, Hidesuke Iwasaki, Masatake Hori, Satoshi Horii
Rok vydání:	1973
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Protein primary structure Fatty acid Peptide General Chemistry General Medicine Amino acid Drug Discovery Aspartic acid Peptide bond Peptide sequence Lactone
Zdroj:	Chemical and Pharmaceutical Bulletin. 21:1175-1183
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.21.1175
Popis:	The primary structure of enduracidin, a cyclodepsipeptide antibiotic, was estimated by the determination of the amino acid sequence, optical isomers of each amino acid, and lactone structure. The result is that the enduracidin has a macro-ring lactone structure which is composed of 16 amino acids, and has a side chain aspartic acid which is connected to a fatty acid by an amide bond. The tentative structure is shown in Fig. 7.
Databáze:	OpenAIRE
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