Asymmetric synthesis of optically active vinyltetrahydrofurans via palladium-catalysed cyclisation of bis(hydroxymethyl)allylic carbonates

Autor:	Stanislaw Porwanski, Agnieszka Kubiak, Izabela Szulc, Beata Olszewska, Anna Zawisza, Boguslaw Kryczka
Rok vydání:	2013
Předmět:	Allylic rearrangement Organic Chemistry Enantioselective synthesis chemistry.chemical_element Optically active Medicinal chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Hydroxymethyl Physical and Theoretical Chemistry Tetrahydrofuran Palladium
Zdroj:	Tetrahedron: Asymmetry. 24:212-216
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2013.01.012
Popis:	Optically active 3-alkyl-3-hydroxymethyl-5-vinyltetrahydrofurans were synthesised from the corresponding methyl or isobutyl carbonates of ω,ω-bis(hydroxymethyl)-α,β-unsaturated alcohols via palladium-catalysed cyclisation. The use of chiral ligands gave the corresponding tetrahydrofuran derivatives, which had er values that ranged from moderate to good.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f303091c8bb5be3e4c6c592dda3b560f https://doi.org/10.1016/j.tetasy.2013.01.012 Zobrazit plný text záznamu Full Text from ScienceDirect