Utilization of analgesics in the multicenter study of hydroxyurea in sickle cell anemia: Effect of sex, age, and geographical location

Autor: Robert L. Bauserman, Wally R. Smith, William F. McCarthy, Samir K. Ballas, Myron A. Waclawiw, Oswaldo Castro
Rok vydání: 2010
Předmět:
Zdroj: American Journal of Hematology. 85:613-616
ISSN: 1096-8652
0361-8609
DOI: 10.1002/ajh.21750
Popis: Several factors affect the severity and duration of sickle cell pain and its response to treatment with analgesics [1,2]. Sex has been one of the factors reported to influence the pain experience and the response to therapy [3]. Several chronic pain disorders, such as fibromyalgia, occur more frequently in females than in males [4,5]. Moreover, women seem to be more sensitive to painful stimuli than men [6]. However, whether differences in analgesic use by sex occur in patients with sickle cell anemia (SS) is unknown. Age also has been related to pain experience in many studies [7―9]. Moreover, we and others recently found an effect of geographic location and climatic conditions on frequency and severity of sickle cell pain [10,11]. Studies at single sites and anecdotal reports showed that climatic conditions, especially temperature can precipitate or exacerbate pain in sickle cell disease [12― 14]. However, to the best of our knowledge, there are no multicenter, randomized, and placebo-controlled studies that relate all of these factors to pain management in sickle cell disease (SCD). The Multicenter Study of Hydroxyurea (MSH) in SS [15] gave us an opportunity to report on these aspects of sickle cell pain.
Databáze: OpenAIRE
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