Synthesis and Study of Biological Activity of Sulfamic Polysaccharide Derivatives
| Autor: | Sh. A. Shomurotov, O. R. Akhmedov, A. S. Turaev, G. G. Rakhmanova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
food.ingredient
Pectin Starch Proteus vulgaris macromolecular substances 02 engineering and technology Polysaccharide 01 natural sciences Biochemistry chemistry.chemical_compound food Sulfamic acid Agar diffusion test chemistry.chemical_classification biology 010405 organic chemistry Organic Chemistry food and beverages Biological activity 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences chemistry 0210 nano-technology Antibacterial activity Nuclear chemistry |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 43:716-721 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | New water-soluble derivatives of starch, pectin, and Na-CMC containing the sulfamic groups have been obtained by the reaction of sulfamic acid with dialdehyde polysaccharide derivatives. The structure and composition of the resulting compounds have been studied by IR spectroscopy, elemental (nitrogen and sulfur) analysis, and X-ray diffraction. The sulfamic derivatives of starch, pectin, and Na-CMC with a different content of the sulfamic groups have been obtained by varying the ratio of sulfamic acid to the dialdehyde polysaccharide derivatives. The optimal–СНО: NH2SO3H ratio was found to be 1: 2.5. The interaction rate of sulfamic acid with the dialdehyde derivatives of starch, pectin, and Na-CMC has been evaluated. The antibacterial and antifungal effects of sodium salts of the sulfamic starch, pectin, and Na-CMC derivatives against Gram-positive and Gram-negative bacteria and fungi have been studied at different concentrations (10, 25, 50 mg/mL) by the disk diffusion method. The synthesized compounds have not been found to exhibit antifungal activity against Candida albicans. Nevertheless, they have been shown to have the antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus vulgaris, Streptococcus faecalis, Streptococcus pyogenes, and Streptococcus faecalis at the concentration of 50 mg/mL. The concentration dependence of antibacterial action of sodium salts of the starch, pectin, and Na-CMC sulfamic derivatives has been demonstrated. The antibacterial activity of the drugs has been found to directly depend on the content of the sulfamic groups in polysaccharides. The results on the acute toxicity of the sulfamic polysaccharide derivatives have shown that these compounds can be attributed to low-toxicity substances of Class V. |
| Databáze: | OpenAIRE |
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