Antibodies reacting with thymus and skin epithelium and antibodies to cell nuclei during immunization with group A streptococcal polysaccharide conjugated with synthetic polyelectrolytes

Autor:	Khaitov Rakhim M, N. A. Borodiyuk, V. Yu. Kolesnikova, E. Yu. Pyt'eva, E. V. Ryzhikova, I. M. Lyampert, Nekrasov Av
Rok vydání:	1987
Předmět:	biology Chemistry Cell Autoantibody General Medicine Group A Molecular biology General Biochemistry Genetics and Molecular Biology Epithelium medicine.anatomical_structure Autoimmune Process Immunization Biochemistry Affinity chromatography medicine biology.protein Antibody
Zdroj:	Bulletin of Experimental Biology and Medicine. 103:805-808
ISSN:	1573-8221 0007-4888
Popis:	Cross sections have been described between group A streptococcal polysaccharides (AgPSC~ in the epithelium of the skin and thymus [3, ii]. As a result of isolation of the antibodies by affinity chromatography it was found [I] that only some antibodies to A-PSC, namely highaffinity antibodies, will react with epithelium. It has been suggested [Ii] that antibodies arising during streptococcal infection to a cross-reacting (CR) determinant of A-PSC can injure the epithelial tissue of the sinus and induce immunoregulatory disturbances leading to the development of an autoimmune process.
Databáze:	OpenAIRE
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