Interleukin-4 mediates CDS induction on human CD4+ T-cell clones
| Autor: | X Paliard, Renè de Waal Malefijt, Jan E. de Vries, Hergen Spits |
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| Rok vydání: | 1988 |
| Předmět: | |
| Zdroj: | Nature. 335:642-644 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/335642a0 |
| Popis: | CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex1,2. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cells express CD4 and CD8 simultaneously3. These mature, double positive cells could be intermediates between CD4+CD8+ thymocytes and mature, single positive T cells, or they may originate from single positive T cells that acquire either CD4 or CD8. Here we report that activation and culturing of cloned CD4+ T cells in interleukin-4 (IL-4), results in the acquisition of CD8 due to its de novo synthesis. The IL-4-induced co-expression of CD8 on CD4+ T cells is reversible, in that CD8 disappeared from double positive T-cell clones isolated in IL-4, when they were cultured in IL-2. CD8 induced by IL-4 can be functional as a monoclonal antibody to CD8 inhibited anti-CD3-mediated cytotoxicity by a double positive T-cell clone. |
| Databáze: | OpenAIRE |
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