β -Cyclodextrin as a supramolecular catalyst for the synthesis of 2 H -indazolo[2,1- b ]phthalazine-trione derivatives in water and their antimicrobial activities
| Autor: | Manisha A. Khande, Priyanka K. Bhadke, Charansingh H. Gill, Jaiprakash N. Sangshetti, Asha V. Chate |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Phthalic anhydride Cyclodextrin 010405 organic chemistry Succinic anhydride General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences Aldehyde 0104 chemical sciences chemistry.chemical_compound chemistry Dimedone Organic chemistry Phthalazine Hydrate Nuclear chemistry |
| Zdroj: | Chinese Chemical Letters. 28:1577-1582 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2017.03.007 |
| Popis: | An efficient and green method has been developed for the synthesis of 2 H -indazolo[2,1- b ]phthalazine-triones derivatives by employing 15 mol% β -cyclodextrin via a one-pot multicomponent reaction of aldehyde, dimedone, hydrazine hydrate with succinic anhydride/phthalic anhydride in water at 80 °C for first time. The catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity and evaluated for in vitro antimicrobial activity against different Gram-positive and Gram-negative bacterial strains. The outcome of the screening study showed that compound 6d , 6f and 7n exhibited excellent activity against E. coil. Whereas, compound 6f and 6 h exhibited excellent activity against P. aeurginosa, and compound 6c , and 6e displayed again excellent activity against Staphylococcus aureus whereas compound 7o shows excellent activity against S. aureus and B. subtilis when compared with Ampicillin (standard control). The results indicated that maximum compounds are moderately effective against bacterial growth and their effectiveness is highest against standard drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect