| Autor: |
Yong-Balk Cho, Eun Ju Lee, Hyun Suk Jeon, Mi-Sook Dong, Yang-Hee Joo, Jung Bum Yi, Jin-soo Seo, Yong Seog Jeon, Cheol Min Yoon, Sung-Eun Yoo, Young-Dae Gong, Jong Yeon Hwang, Namkyu Lee, Wie Jong Kwak |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Bulletin of the Korean Chemical Society. 27:909-917 |
| ISSN: |
0253-2964 |
| DOI: |
10.5012/bkcs.2006.27.6.909 |
| Popis: |
2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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