Study of reaction of gossypol and its imino derivatives with 2,2-diphenyl-1-picrylhydrazyl

Autor:	Grzegorz Schroeder, K. Yu. Chotii, A. F. Dmitruk, N. S. Il’kevich, V. I. Rybachenko
Rok vydání:	2010
Předmět:	Ethanol Schiff base Antioxidant Chemistry DPPH medicine.medical_treatment General Chemistry Nuclear magnetic resonance spectroscopy chemistry.chemical_compound Polyphenol General chemistry Gossypol medicine Organic chemistry Nuclear chemistry
Zdroj:	Russian Journal of General Chemistry. 80:301-307
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363210020192
Popis:	Structures and state in solutions of natural polyphenol gossypol and four its imino derivatives, three of which were synthesized for the first time, were studied by IR and NMR spectroscopy, and by quantum chemistry. The reaction of these compounds with 2,2-diphenyl-1-picrylhydrazyl (DPPH) in ethanol was examined. The antioxidant activity of the studied compounds in the reaction with DPPH was evaluated using the values of the stoichiometric coefficients of reaction, EC50, T12/DPPH and AE parameters. Gossypol hydrazones were shown to be 5–10 times more efficient, while Schiff base to be less efficient as antioxidants in comparison with gossypol itself. The influence of metal cations on the antioxidant activity of gossypol derivatives was studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f2d2161ece408ec346ba81546381247d https://doi.org/10.1134/s1070363210020192 Zobrazit plný text záznamu Plný text ve formátu PDF