Evaluation of in Vitro Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent
| Autor: | Norihisa Noguchi, Keisuke Nakase, Shoji Seyama, Akifumi Hagi, Hidemasa Nakaminami, Takeaki Wajima, Hisae Nishioka |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology biology Klebsiella pneumoniae Pseudomonas aeruginosa Biguanide medicine.drug_class Chemistry Disinfectant Pharmaceutical Science General Medicine biology.organism_classification medicine.disease_cause Enterococcus faecalis Microbiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Staphylococcus epidermidis Staphylococcus aureus 030220 oncology & carcinogenesis medicine Candida albicans |
| Zdroj: | Biological and Pharmaceutical Bulletin. 42:512-515 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b18-00821 |
| Popis: | Recently, 1.5% olanexidine gluconate, a biguanide compounds, was launched as a new antiseptic agent in Japan. However, the comprehensive bactericidal spectrum of olanexidine gluconate is still unknown. In this study, we evaluated in vitro bactericidal activity of olanexidine gluconate using time-kill assay against various bacteria, mycobacteria, and fungi. With the exception of Burkholderia cepacia and Mycobacterium spp., 1.5% olanexidine gluconate exhibited fast-acting (≤60 s) bactericidal activity against all tested Gram-positive and Gram-negative bacteria, including vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, extended spectrum β-lactamase producing Klebsiella pneumoniae, and multidrug-resistant Pseudomonas aeruginosa. Furthermore, 1.5% olanexidine gluconate eradicated Candida albicans, Microsporum canis, and Malassezia furfur within 3 min. Our findings indicate that olanexidine gluconate has broad spectrum bactericidal activity; therefore, it may be useful for the prevention of a wide range of infectious diseases. |
| Databáze: | OpenAIRE |
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