Prediction of drug release by characterisation of the tortuosity in porous cellulose beads using a spin echo NMR technique

Autor:	Ragnar Ek, U. Henriksson, L. ödberg, H. Nyqvist, Christer Nyström, T. Gren
Rok vydání:	1995
Předmět:	chemistry.chemical_compound chemistry Drug release Analytical chemistry Spin echo Pharmaceutical Science Cellulose Drug carrier Porosity Tortuosity Dissolution Dosage form
Zdroj:	International Journal of Pharmaceutics. 124:9-18
ISSN:	0378-5173
DOI:	10.1016/0378-5173(95)00065-q
Popis:	The tortuosity of pores in cellulose beads has been estimated using a spin echo NMR technique and by direct release measurements. The tortuosity determined with NMR was slightly higher ( r = 2.7) than the values obtained from direct release measurements ( r = 1.6-2.4). The deviations are explained in terms of unfulfilled prerequisites for the models describing the dissolution process. Another explanation may be differences in drug loading and pore structure in the outer and inner layer of the porous cellulose beads. The NMR measurements are described in detail and special problems occurring when applying this technique are discussed. In this work it is shown to be possible to predict drug release from structural data of porous cellulose beads.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f2b9685191465074e43fecc81668b4c2 https://doi.org/10.1016/0378-5173(95)00065-q Zobrazit plný text záznamu Full Text from ScienceDirect