Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer

Autor:	Nuria Viñolas, Alfons Navarro, Tania Díaz, Angels Quera, Bernat Gel, Marc Campayo, Elena Gallardo, José Ramírez, Eva Bandrés, Jesús García-Foncillas, Ramon M. Marrades, Mariano Monzo
Rok vydání:	2010
Předmět:	Oncology Pathology medicine.medical_specialty Multivariate analysis Oncogene Proportional hazards model business.industry Retrospective cohort study General Medicine medicine.disease Internal medicine microRNA medicine Carcinoma Surgery Lung cancer business Survival rate
Zdroj:	Journal of Surgical Oncology. 103:411-415
ISSN:	0022-4790
DOI:	10.1002/jso.21847
Popis:	Background MicroRNAs are novel regulators of gene expression that are linked to the main oncogene networks, including the p53 pathway. p53 regulates the maturation process of miR-16 and miR-143. We analyzed the role as prognostic markers of miR-16 and miR-143 in 70 non-small-cell lung cancer (NSCLC) patients. Methods MicroRNAs were analyzed by TaqMan MicroRNA assays. Disease-free survival (DFS) and overall survival (OS) were examined using Kaplan–Meier curves with log-rank tests and the Cox proportional hazard model. Results When patients were classified in three groups according to their miR-16 expression levels, those with normal levels had the best outcome while those with high levels had the worst. DFS was 22.4 months for patients with high levels, 71.8 months for those with normal levels, and 55.8 months for those with low levels (P = 0.05). OS was 23.9 months for patients with high levels, 97.6 months for those with normal levels, and 63.5 months for those with low levels (P
Databáze:	OpenAIRE
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