Metal complexes of porphyrin–anthraquinone hybrids: DNA binding and photocleavage specificities

Autor:	Jin-Wang Huang, Liang-Nian Ji, Ping Zhao
Rok vydání:	2011
Předmět:	Gel electrophoresis Steric effects Circular dichroism Chemistry Free base Photochemistry Porphyrin Anthraquinone Metal chemistry.chemical_compound visual_art Polymer chemistry Materials Chemistry visual_art.visual_art_medium Physical and Theoretical Chemistry DNA
Zdroj:	Journal of Coordination Chemistry. 64:1977-1990
ISSN:	1029-0389 0095-8972
DOI:	10.1080/00958972.2011.585641
Popis:	A cationic porphyrin–anthraquinone hybrid and its Zn(II), Cu(II), Co(III), and Mn(III) complexes were synthesized and their interactions with duplex DNA were studied using a combination of absorption, fluorescence titration, circular dichroism spectroscopy, thermal DNA denaturation, viscosity measurements, gel electrophoresis, and gas chromatography. Metal coordination induces intermolecular steric hindrance and thus the metal hybrids have smaller DNA binding affinities than the free base hybrid; the steric hindrance could relax the intermolecular aggregation and increase 1O2 generation of the metal hybrids. The DNA photocleavage abilities of these hybrids were investigated.
Databáze:	OpenAIRE
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