Carcinoid of the uterine cervix.Additional observations on a new tumor entity
| Autor: | Siria Poucell, Jorge Albores-Saavedra, Oscar Larraza, Héctor A Rodríguez Martínez |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Cancer Research
education.field_of_study Pathology medicine.medical_specialty Lung Neuroendocrine carcinoma of the cervix business.industry Carcinoid tumors Thyroid Population Enteroendocrine cell medicine.disease medicine.anatomical_structure Oncology Medullary carcinoma medicine education business Cervix |
| Zdroj: | Cancer. 38:2328-2342 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(197612)38:6<2328::aid-cncr2820380620>3.0.co;2-j |
| Popis: | Twelve carcinoid tumors of the uterine cervix were studied. Based on the microscopic structure, they were divided into well-differentiated and poorly differentiated types. Both tumor varieties affected adult women. The clinical and gross features of these tumors were indistinguishable from those of invasive squamous cell carcinoma. Of the 12 patients, six died, four with poorly differentiated carcinoid and two with the well-differentiated type. Three patients are alive and symptom-free 9 months to 2 years after treatment; the remaining three were lost to follow-up. Microscopically, four well-differentiated carcinoids showed argyrophil cells, and ultrastructurally two had neurosecretory granules. One of the well-differentiated carcinoids resembled islet cell carcinoma and two had areas resembling medullary carcinoma of the thyroid. The poorly differentiated type of carcinoid had a histologic structure and a cell population very similar to that of the oat cell carcinoma of the lung. Of this group, four were argyrophilic, and by electron microscopy four contained pleomorphic secretory granules. It is considered that these tumors arise from the normal argyrophil cell of the cervix and are part of the group of neoplasms of the diffuse endocrine cell system (APUD). |
| Databáze: | OpenAIRE |
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