Biocompatible palm stearin-based polyesteramide as polymer carrier for solid dispersion
| Autor: | Wen Huei Lim, Wei Seng Wong, Choy Sin Lee, Shew Fung Wong, Hui Meng Er |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Diethanolamine
Azelaic acid Materials science Polymers and Plastics 02 engineering and technology 010402 general chemistry 01 natural sciences Dosage form Gel permeation chromatography chemistry.chemical_compound Differential scanning calorimetry Polymer chemistry Materials Chemistry medicine chemistry.chemical_classification General Chemistry Polymer 021001 nanoscience & nanotechnology Palm stearin 0104 chemical sciences Surfaces Coatings and Films chemistry Stearic acid 0210 nano-technology medicine.drug Nuclear chemistry |
| Zdroj: | Journal of Applied Polymer Science. 135:45892 |
| ISSN: | 0021-8995 |
| Popis: | Palm stearin-based polyesteramide (PSPEA) was synthesized by reacting PS with diethanolamine, followed by azelaic acid at functionality molar ratio (OH: COOH) ranged 1:0.84 to 1:0.95 at 150–190 °C. FTIR, 1H-nuclear magnetic resonance, 13C-nuclear magnetic resonance, and gel permeation chromatography were used to elucidate the chemical structure and Mw distribution of the PSPEA. PSPEA 4000 (acid value = 0.61 mg KOH/g sample, hydroxyl value = 51.97 mg KOH/g sample) was used in combination with stearic acid-based PEA to prepare mefenamic acid (MA) solid dispersion. The solid dispersion demonstrated sixfold and twofold enhancement in T50% and cumulative drug release as compared to pure MA. The differential scanning calorimetry and scanning electron microscopy analyses revealed solubilization of MA in PEA and transformation of MA into amorphous. In vitro cytotoxicity studies confirmed the safety profile of PSPEA against 3T3 fibroblast cell lines. This work demonstrated that the biocompatible PSPEA possesses surface tension lowering and anticrystallization effects have the potential as polymer carrier for pharmaceutical dosage forms. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45892. |
| Databáze: | OpenAIRE |
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