In vitro and In vivo Neutralizing Activity of Uvaria Chamae Fractions on the Venoms of Naja Nigricollis in Albino Rat and Bovine Blood

Autor:	P.O. Yusuf, M.P. Ameh, G. Ada, M.G. Magaji, M. Mamman
Rok vydání:	2020
Předmět:	Uvaria chamae biology Traditional medicine Ethyl acetate General Medicine biology.organism_classification Median lethal dose In vitro chemistry.chemical_compound chemistry In vivo Bovine blood Naja nigricollis Envenomation
Zdroj:	British Journal of Pharmacology and Toxicology. 10:1-11
ISSN:	2044-2467 2044-2459
DOI:	10.19026/bjpt.10.6035
Popis:	This study was aimed at evaluating the effect of Uvaria chamae extract in protecting against Naja nigricollis envenomations. Uvaria chamae is a well-known medicinal plant in Nigeria traditional medicine for the management of snakebite. Freshly collected Uvaria chamae leaves and stems were air-dried, powdered and extracted in methanol. The median lethal dose of the extract was determined and further fractionated with n-hexane, n-butanol, and ethyl acetate. Each fraction was tested for neutralizing effect against venom-induced haemolytic, fibrinolytic, hemorrhagic, and cytotoxic activities. The result obtained showed significant (p 0.05) increased. Antifibrinolytic activity was significantly (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f289a46a61f0a901016452176b5c323d https://doi.org/10.19026/bjpt.10.6035 Zobrazit plný text záznamu