Sleep Disturbances and Diminished Quality of Life in Postural Tachycardia Syndrome
| Autor: | David Robertson, Bonnie K. Black, John F. Ling, Kanika Bagai, Italo Biaggioni, Satish R. Raj, Beth A. Malow, Yanna Song |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Sleep disorder medicine.medical_specialty Sleep terror medicine.disease Chest pain Sleep in non-human animals Orthostatic vital signs Neurology Quality of life Heart rate Postural Orthostatic Tachycardia Syndrome medicine Physical therapy Neurology (clinical) medicine.symptom Psychology |
| Zdroj: | Journal of Clinical Sleep Medicine. :204-210 |
| ISSN: | 1550-9397 1550-9389 |
| DOI: | 10.5664/jcsm.28110 |
| Popis: | Postural tachycardia syndrome (POTS) affects an estimated 500,000 people in the United States alone. POTS is defined as excessive increase in heart rate (≥ 30 beats/min) with upright posture, associated with orthostatic symptoms including palpitation, chest pain syndrome, dyspnea on standing, mental clouding, and difficulties with concentration in the absence of orthostatic hypotension. It can produce substantial disability among otherwise healthy people.1,2 The pathophysiology of POTS is poorly understood, however many patients suffer from either a primary or secondary increase in sympathetic nervous system tone.3 Patients with POTS commonly complain of symptoms including fatigue and difficulty with sleep. One study found that patients with POTS had a diminished quality of life when measured using a standard health status instrument (SF-36).4 There are no published data, however, on the quality of sleep or sleep disturbances in patients with POTS. Conversely, problems with autonomic nervous system regulation have been noted in several primary disorders of sleep. These include relatively common sleep disorders such as obstructive sleep apnea5–7 and less common disorders such as fatal familial insomnia, sleep terrors, and REM sleep behavior disorder.8–10 Recent studies have shown that subjective poor sleep is associated with reduced physical performance, greater functional limitation, increased risk for cardiovascular diseases, and may even predict all-cause mortality.11–14 Therefore poor sleep may be a core factor associated with the low quality of life reported by patients with POTS. BRIEF SUMMARY Current Knowledge/Study Rationale: Patients with POTS commonly complain of symptoms including fatigue and difficulty with sleep. Prior to this paper, there were no published data on the quality of sleep or sleep disturbances in patients with POTS. Study Impact: This study found that patients with POTS have poor sleep quality, excessive sleepiness, excessive fatigue, and a high proportion of diminished quality of life due to sleep problems. Further objective sleep assessments are needed to delineate the specific sleep problems in patients with POTS, which will be a pre-requisite to develop optimal treatments. The aim of this study was to formally assess sleep quality, fatigue, and health-related quality of life (HRQL) in patients with POTS as compared with healthy control subjects. |
| Databáze: | OpenAIRE |
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