Prevalence and associations of anti-phosphatidylserine/prothrombin antibodies with clinical phenotypes in patients with primary antiphospholipid syndrome
| Autor: | Paola Bermúdez-Bermejo, Gabriela Hernández-Molina, Diego F. Hernández-Ramírez, Elizabeth Olivares-Martínez, Antonio R. Cabral, Victor Zamora-Legoff, Carlos A. Núñez-Álvarez |
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| Rok vydání: | 2019 |
| Předmět: |
Hemolytic anemia
medicine.medical_specialty Lupus anticoagulant biology business.industry Hematology 030204 cardiovascular system & hematology medicine.disease Gastroenterology Thrombosis Serology 03 medical and health sciences Titer 0302 clinical medicine Antiphospholipid syndrome 030220 oncology & carcinogenesis Internal medicine medicine biology.protein Clinical significance Antibody business |
| Zdroj: | Thrombosis Research. 174:141-147 |
| ISSN: | 0049-3848 |
| Popis: | Objective The clinical significance of anti-phosphatidylserine/prothrombin (aPS/PT) in antiphospholipid syndrome (APS) is still controversial. We assessed the prevalence of aPS/PT antibodies, their association with other anti-phospholipid antibodies (aPL) and with different APS clinical phenotypes. Methods We included 95 primary APS patients according to the Sydney classification criteria, and patients with thrombocytopenia and/or hemolytic anemia who also fulfilled the serological APS criteria. We tested aCL, anti-β2GP-I and aPS/PT antibodies (both IgG and IgM isotypes) and lupus anticoagulant (LA). We used χ2 test, Spearman's correlation coefficient, Mann-Whitney U test and logistic regression. Results Seventy-seven percent of patients had thrombosis, 50% hematologic involvement and 25% obstetric events (non-exclusive groups). Twenty patients had only hematologic features. The prevalence of IgG and IgM aPS/PT antibodies was 61% and 60%, respectively. Patients with LA+ had a higher prevalence and higher titers of IgG and IgM aPS/PT antibodies. aPS/PT antibodies correlated with aPL antibodies including LA. IgG aPS/PT antibodies were associated with thrombosis (OR 8.6 [95% CI 2.13–33.8, p = 0.002]) and pure hematologic features (OR 0.2, CI 95% 0.05–0.97, p = 0.004). IgM anti-β2GP-I antibodies conferred high risk for both hematologic (OR 7.9, 95% CI 1.88–34.61, p = 0.006) and thrombotic involvement (OR 7.4, 95% CI 1.76–31.12, p = 0.006). Conclusions aPS/PT antibodies were highly prevalent and correlated with other aPL antibodies. IgG aPTS/PT conferred a high risk for thrombosis, but not for pure hematologic involvement. aPS/PT antibodies may be a useful serological tool in the diagnosis and phenotypic characterization of APS patients. |
| Databáze: | OpenAIRE |
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