Differentiation of Deprotonated Acyl-, N-, and O-Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation
| Autor: | Hilkka I. Kenttämaa, Edouard Niyonsaba, John Kong, Leah F. Easterling, Mckay W Easton, Zhoupeng Zhang, Harry R. Chobanian, Gozdem Kilaz, Huaming Sheng, Erlu Feng, Nicholas R. Deprez, Zaikuan Yu, Jacob Milton, Mark T. Cancilla |
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| Rok vydání: | 2019 |
| Předmět: |
Stereochemistry
010401 analytical chemistry Glucuronidation Conjugated system 010402 general chemistry Tandem mass spectrometry Glucuronic acid 01 natural sciences Dissociation (chemistry) 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Deprotonation chemistry Glucuronide Drug metabolism |
| Zdroj: | Analytical Chemistry. 91:11388-11396 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/acs.analchem.9b02717 |
| Popis: | Glucuronidation, a common phase II biotransformation reaction, is one of the major in vitro and in vivo metabolism pathways of xenobiotics. In this process, glucuronic acid is conjugated to a drug ... |
| Databáze: | OpenAIRE |
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