Oncogeni ed integrine nel carcinoma prostatico: Oncogenes and integrine in prostate cancer

Autor:	Roberto Tarabuzzi, S. Cappia, E. Leonardo, Dario Fontana, G. Fasolis, M. Mari
Rok vydání:	1995
Předmět:	Prostate cancer business.industry Cancer research medicine Carcinoma General Medicine medicine.disease business
Zdroj:	Urologia Journal. 62:39-43
ISSN:	1724-6075 0391-5603
DOI:	10.1177/039156039506200108
Popis:	We studied the c-ras oncogene and p53 oncosuppressorgene products (p21, p53) and also some integrine in prostatic cancer and BPH patients to evaluate a possible prognostic value. p21 was detected only in cancer tissue without any significant difference between different stages and grades of prostatic disease. p53 was more expressed in prostatic cancer than BPH, without any statistical difference. No correlation between p53 expression and different stages and grades was demonstrated. Fibronectin receptor (integrin) was significantly higher in cancer than BPH (P < 0,05). p53 expression, only in stage D patients, was related to a significant shorter progression time (P < 0,0001). Fibronectin receptor correlated with a significantly higher progression risk (Odds Ratio = 2,5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f267c60847a3036db301814abddc0243 https://doi.org/10.1177/039156039506200108 Zobrazit plný text záznamu