An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer
| Autor: | Trent P. Munro, Martina L. Jones, Michael J. Monteiro, Christopher B. Howard, Stephen M. Mahler, Stephen Francis Goodall, Zhongfan Jia |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Liposome Renewable Energy Sustainability and the Environment General Chemical Engineering Organic Chemistry food and beverages Nanoparticle Nanotechnology Polymer Pollution Self assembled Inorganic Chemistry Fuel Technology chemistry Dendrimer Drug delivery Self-healing hydrogels Particle size Waste Management and Disposal Biotechnology |
| Zdroj: | Journal of Chemical Technology & Biotechnology. 90:1222-1229 |
| ISSN: | 0268-2575 |
| Popis: | BACKGROUNDDecorating nanoparticles with proteins, antibodies and antibody fragments allows highly specific targeting to selected cells for improved delivery of therapeutics and diagnostics. A range of particles have previously been trialled in drug delivery including liposomes, dendrimers, hydrogels and inorganic particles. Polymer nanoparticles can be rationally designed and self-assembled with control over particle size, morphology, charge and shape, allowing for optimization of drug delivery. However, post-functionalization of particles with antibodies or proteins can influence the self-assembly process and creates challenges in maintaining bioactivity. |
| Databáze: | OpenAIRE |
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