Sequential Ugi/Heck cyclization strategies for the facile construction of highly functionalized N -heterocyclic scaffolds

Autor:	Vijaya Gracias, Stevan W. Djuric, Joel D. Moore
Rok vydání:	2004
Předmět:	Molecular complexity Chemistry Stereochemistry Intramolecular force Organic Chemistry Drug Discovery Multi-component reaction Sequence (biology) Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 45:417-420
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.10.147
Popis:	A new strategy employing an Ugi four-component reaction and a microwave-assisted intramolecular Heck cyclization in a sequential fashion to access an array of N-containing heterocycles is reported. The two-step sequence generated compounds of significant molecular complexity from trivial starting materials in an expedient fashion with excellent yields. The route was also amenable to solid-phase chemistry demonstrating potential for library generation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f25d64eff64d94e7b5a10a329bbc0d06 https://doi.org/10.1016/j.tetlet.2003.10.147 Zobrazit plný text záznamu Full Text from ScienceDirect