Dose distribution in boron neutron capture therapy for the treatment of brain cancer
| Autor: | R. S. Dutra, Renato Pereira de Freitas, Ademir Xavier da Silva, Elicardo A.S. Gonçalves, Valter S. Felix, André Rocha Pimenta, Douglas S. R. Ferreira, Leandro de Oliveira Pereira |
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| Rok vydání: | 2020 |
| Předmět: |
Radiation
Materials science 010308 nuclear & particles physics business.industry Monte Carlo method Gamma ray Parietal lobe computer.software_genre 01 natural sciences Neutron temperature 030218 nuclear medicine & medical imaging 03 medical and health sciences Neutron capture 0302 clinical medicine Frontal lobe Voxel 0103 physical sciences Nuclear medicine business computer Beam (structure) |
| Zdroj: | Radiation Physics and Chemistry. 168:108611 |
| ISSN: | 0969-806X |
| Popis: | This work presents a study of the influence of the field size of an epithermal neutron beam on the dose distribution in treatments with boron neutron capture therapy using an anthropomorphic voxel-based simulator. To calculate the doses in the tissues and organs of the head, the Monte Carlo N-Particle radiation transport code is used. The results suggest the possibility of using a beam of 6 cm in diameter for the treatment of tumours in the frontal lobe and parietal regions. With a beam of 10 cm in diameter, we could treat tumours located in the frontal lobe, parietal lobe and thalamus. The work also shows that the contribution of the secondary components (gamma rays, fast and thermal neutrons) in the calculation of the total dose can result in up to 15% of the dose in the tumour tissue, 68% of the dose in the healthy brain tissue and 87% of the dose in the non-cephalic regions. |
| Databáze: | OpenAIRE |
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