Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults
| Autor: | Robert M. Kelsey, Mary K. Dahmer, Bruce S. Alpert, Julia Krushkal, Michael W. Quasney |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Endocrine and Autonomic Systems Cognitive Neuroscience General Neuroscience Hemodynamics Experimental and Cognitive Psychology Alpha Adrenergic Receptor Gene Neuropsychology and Physiological Psychology medicine.anatomical_structure Blood pressure Endocrinology Developmental Neuroscience Neurology Polymorphism (computer science) Internal medicine Heart rate Vascular resistance medicine Psychology Beta (finance) Video game Biological Psychiatry |
| Zdroj: | Psychophysiology. 49:401-412 |
| ISSN: | 0048-5772 |
| DOI: | 10.1111/j.1469-8986.2011.01319.x |
| Popis: | Cardiovascular reactivity to stress and beta-adrenergic receptor (beta-AR) function may contribute to the development of hypertension. As Black Americans have an increased risk of hypertension, we evaluated associations between beta(1)-AR (Arg389Gly) and beta(2)-AR (Arg16Gly, Gln27Glu) gene variants and cardiovascular reactivity in 500 Black youth. Heart rate, preejection period, total peripheral resistance, and blood pressure reactivity were measured during cold and psychological stress. The Arg389Gly polymorphism in the beta(1)-AR was associated with preejection period reactivity in males but not in females. The Arg16Gly polymorphism in the beta(2)-AR was associated with diastolic blood pressure reactivity only during video game stress. An association between the Gln27Glu polymorphism in the beta(2)-AR and vascular reactivity depended on sex. Thus, specific patterns of associations emerged between genetic variations in beta-ARs and cardiovascular reactivity in young Blacks. |
| Databáze: | OpenAIRE |
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