Formation of hyaluronic acid–ellagic acid microfiber hybrid hydrogels and their applications
| Autor: | Stacey N. Barnaby, Karl R. Fath, Stephen H. Frayne, Nako Nakatsuka, Ipsita A. Banerjee |
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| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
Biocompatibility Chemistry chemistry.chemical_compound Colloid and Surface Chemistry Drug delivery Polymer chemistry Self-healing hydrogels Hyaluronic acid Materials Chemistry medicine Crystal violet Physical and Theoretical Chemistry Swelling medicine.symptom Histidine Nuclear chemistry Ellagic acid |
| Zdroj: | Colloid and Polymer Science. 291:515-525 |
| ISSN: | 1435-1536 0303-402X |
| DOI: | 10.1007/s00396-012-2739-2 |
| Popis: | Microfiber assemblies prepared from ellagic acid (EA) were functionalized with histidine (His) and dispersed in hyaluronic acid (HA) hydrogel microstructures. Swelling studies indicated that the hybrids had a relatively lower water uptake compared to HA and was pH dependent. The percentage swelling ratio for EA–His–HA hybrids was 48 % when 0.04 mg/mL of HA was incorporated and increased to 70 % when 1.2 mg/mL HA was integrated. Release studies using the dye crystal violet (CV) as a model drug showed that the rates were concentration-dependent. Further the hybrids were found to be thermally stable compared to HA. Cellular toxicity assays performed with normal rat kidney (NRK) cells indicated biocompatibility and adherence of the hybrids to the cells. Thus, we have developed a new family of hybrid hydrogels which readily formed on the EA–His functionalized microfibers and may have potential applications in drug delivery or tissue regeneration applications. |
| Databáze: | OpenAIRE |
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