Synthesis of phosphorylated derivatives of isatin with sterically hindered phenol fragments
| Autor: | Rashid Z. Musin, Sergey V. Bukharov, V. V. Syakaev, Roza G. Tagasheva, Alexander R. Burilov, Gulnara N. Nugumanova, Yulia N. Oludina |
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| Rok vydání: | 2016 |
| Předmět: |
Steric effects
chemistry.chemical_classification Double bond 010405 organic chemistry Chemistry Isatin Organic Chemistry 010402 general chemistry Hydrazide Isonicotinic acid 01 natural sciences Biochemistry Phosphonate 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Organic chemistry Phenol Pharmacophore |
| Zdroj: | Phosphorus, Sulfur, and Silicon and the Related Elements. 191:1069-1074 |
| ISSN: | 1563-5325 1042-6507 |
| Popis: | The synthesis of N-[dimethoxyphosphoryl-(3,5-di-tert-butyl-4-hydroxyphenyl)] methylisatins has been performed by the addition of isatin and 5-butylisatin to the double bond of dimethyl-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadienylidene)methylphosphonate. Subsequent functionalization of the compounds synthesized with thiosemicarbazide hydrochloride, 3-(3′,5′-di-tert-butyl-4′-hydroxyphenyl)propionic acid hydrazide, and isonicotinic acid. Hydrazide gave isatin derivatives containing several pharmacophore fragments. Each of them has the ability to the increase the antioxidant and biological activities of these compounds. |
| Databáze: | OpenAIRE |
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