P904 Genetic Variants in IBD Chilean Patients are related to clinical outcomes

Autor: T Pérez, M L Bustamante, D Travisany, F Magne, C Hernandez-Rocha, M Alvarez-Lobos, M Orellana, G Ascui, L Azocar, A Espino, N Aguilar, P Baez, A Zazueta, R Estela, V Silva, S Escobar, A De la Vega, E Arriagada, J F Miquel, D Alvares
Rok vydání: 2023
Předmět:
Zdroj: Journal of Crohn's and Colitis. 17:i1017-i1018
ISSN: 1876-4479
1873-9946
DOI: 10.1093/ecco-jcc/jjac190.1034
Popis: Background IBD has emerged as a worldwide disease with an increased incidence in newly industrialized countries such as Chile. This population has been underrepresented in genome-wide association studies (GWAS) because IBD genetics studies have focused mainly on North America and European populations. In addition, specific IBD risk alleles have been related to different races and ethnicities. Aim: To investigate the association of IBD risk variants reported in previous GWAS studies with clinical outcomes in our Chilean patients. Methods 192 Chilean individuals with IBD (145 UC and 47 CD) were genotyped using Illumina GSA Arrays. From IBD GWAS (Jostin et al. and Liu et al.), we selected gene variants with pGWAS value < 5x10-8 and looked for them in our Chilean IBD group. Then, we built a Chilean dataset (clinical-genotype information). Using this dataset, we performed a Spearman correlation matrix to correlate clinical outcomes with IBD variants. Further, we built regression models to predict the clinical outcomes using the variants obtained from the correlation matrix (p Results As shown in Figure 1 and Table 1, the best predictive regression models (more than 80%) for the clinical outcomes were surgery, Clinical/Endoscopy remission for more than five years, and Naïve anti-TNF. Association with genetic variants was observed significantly (p Conclusion Conclusion. Candidates' genes related to clinical outcomes in our Chilean IBD cohort were related to epithelial, innate, and adaptative immune responses and host-microbial interactions. Future research is needed to validate these findings.
Databáze: OpenAIRE
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