Preparation of Regioselectively Modified Amylose Derivatives and Their Applications in Chiral HPLC
| Autor: | Fuyou Pan, Baishen Sun, Lili Tian, Xiaofang Li, Guihua Liu, Zhaolei Jin, Fang Wang, Shouwan Tang |
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| Rok vydání: | 2012 |
| Předmět: |
Tris
chemistry.chemical_classification Organic Chemistry Clinical Biochemistry Chiralpak AD Polysaccharide Biochemistry High-performance liquid chromatography Chiral resolution Analytical Chemistry Chiral column chromatography chemistry.chemical_compound chemistry Amylose Organic chemistry Chiral derivatizing agent |
| Zdroj: | Chromatographia. 75:1347-1354 |
| ISSN: | 1612-1112 0009-5893 |
| DOI: | 10.1007/s10337-012-2338-x |
| Popis: | Four regioselectively modified amylose derivatives with three different substituents at the 2-, 3-, and 6-positions were prepared and their enantioseparations in HPLC were examined. Investigations indicated that the nature as well as the arrangement of the substituents significantly influenced their enantioseparations and each derivative exhibited characteristic chiral recognition. Amylose 2-benzoyl-3-(3,5-dimethylphenylcarbamate or 3,5-dichlorophenylcarbamate)-6-((S)-1-phenylethylcarbamate) exhibited chiral resolving abilities comparable to the commercial available amylose tris(3,5-dimethylphenylcarbamate)-based column, Chiralpak AD and the racemic compounds shown in this study were most effectively resolved on these two derivatives. The influence of mobile phase on chiral resolution was also examined. |
| Databáze: | OpenAIRE |
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