Standardized method comparison for ACS:180 plus and Immulite sensitive PSA (sPSA) measurement methods
| Autor: | Yusuf Kurtulmus, Tijen Tanyalcin, Giray Bozkaya, Biltan Ersöz, Oguzhan Gündüz, Ömür Cerci, F Kutay |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Measurement method
Receiver operating characteristic medicine.diagnostic_test business.industry General Chemical Engineering Regression analysis General Chemistry Deming regression Blood serum Method comparison Immunoassay Statistics medicine Safety Risk Reliability and Quality business Instrumentation Quality assurance Mathematics |
| Zdroj: | Accreditation and Quality Assurance. 6:424-426 |
| ISSN: | 0949-1775 |
| Popis: | The aim of this study was to compare two immunoassay measurement methods, the ACS:180 Plus (Chiron Diagnostics) kit and the Immulite sPSA (DPC) kit. Method comparison analysis was performed according to EP9-A; approved guideline of NCCLS 51. Serum samples having a wide range of total prostate-specific antigen (PSA) concentrations were evaluated in split-sample analysis. F-test, t-test analysis and regression statistics were performed. In Deming regression analysis the coefficients were as follows; the slope=0.967; y-intercept=-0.148, r=0.989. An acceptable bias was seen since the systematical error was calculated to have a value less than the total allowable error calculated from biological variations. Non-parametric evaluation of the area under ROC curves for ACS:180 Plus and Immulite sPSA were 0.997 and 0.987, respectively. Diagnostic accuracy was at the level of p= 0.000 and no statistical difference was found between the two assay methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink