Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise

Autor:	Piotr P. Gorski, Daniel C. Turner, Juma Iraki, James P. Morton, Adam P. Sharples, José L. Areta
Rok vydání:	2023
Předmět:	Physiology Physiology (medical) Endocrinology Diabetes and Metabolism
Zdroj:	American Journal of Physiology-Endocrinology and Metabolism. 324:E437-E448
ISSN:	1522-1555 0193-1849
Popis:	We identify novel epigenetically regulated genes associated with train-low sleep-low paradigms. Exercise under low-carbohydrate (CHO) energy-balance (high-fat) conditions elicited a more prominent DNA hypomethylation signature 30 minutes postexercise compared with low-CHO energy-deficit (low-fat) conditions. This was enriched within IL6-JAK-STAT signaling, metabolic processes, p53, cell cycle, oxidative phosphorylation, and fatty acid metabolism. Histone deacetylase (HDAC) family members 2, 4, 10, and 11 demonstrated hypomethylation, with HDAC2 and HDAC11 possessing alternative regulation of gene expression in energy balance versus deficit conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f235657c5d7ff8f3d486ad2941b7d5be https://doi.org/10.1152/ajpendo.00029.2023 Zobrazit plný text záznamu