Enzyme-free uric acid electrochemical sensors using β-cyclodextrin-modified carboxylic acid-functionalized carbon nanotubes
| Autor: | Margaret A. Schwarzmann, Samuel D. Gillespie, Mulugeta B. Wayu, Michael C. Leopold |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Nanocomposite Mechanical Engineering Carboxylic acid 02 engineering and technology Carbon nanotube Glassy carbon 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Amperometry 0104 chemical sciences Electrochemical gas sensor law.invention chemistry.chemical_compound chemistry Chemical engineering Mechanics of Materials law Nafion Organic chemistry General Materials Science 0210 nano-technology Selectivity |
| Zdroj: | Journal of Materials Science. 52:6050-6062 |
| ISSN: | 1573-4803 0022-2461 |
| DOI: | 10.1007/s10853-017-0844-9 |
| Popis: | Carboxylic acid-functionalized multi-walled carbon nanotubes (COOH-MWCNT) were modified via ultrasonication with β-cyclodextrin (β-CD) to obtain a COOH-MWCNT:β-CD nanocomposite material for the purpose of developing an enzyme-free electrochemical sensor for uric acid—a clinically relevant molecule implemented in pregnancy-induced hypertension diagnosis. The nanocomposite material is deposited onto glassy carbon electrodes and subsequently capped with layers of Nafion and Hydrothane polyurethane. The surface morphology and electronic structure of the nanocomposite material were characterized using UV–Vis, TEM, and FTIR. The performance of the electrochemical sensor was measured through direct injection of UA during amperometry. With the high surface area of the COOH-MWCNT in concert with the selectivity provided by β-CD, the composite system outperforms similar COOH-MWCNT systems, displaying enhanced UA sensitivity versus films with only COOH-MWCNT. With the improved sensitivity (4.28 ± 0.11 µA mM−1) and fast response time (4.0 ± 0.5 s), the sensors offer wide detection of UA across clinically relevant ranges (100–700 μM) as well as demonstrated selectivity against various interferents. |
| Databáze: | OpenAIRE |
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